Clymene is an Orchomenian princess, named as the daughter of King Minyas of Orchomenus. Wikipedia treats her among the several mythological figures who bear the name Clymene (Κλυμένη, 'fame'), and she is distinguished from the better-known Oceanid Clymene and from other women of the same name.

Her name is not always stable across the sources. Some authors call her Periclymene or Eteoclymene, while according to others Periclymene and Eteoclymene were instead the names of her sisters. In some accounts Eteoclymene, Periclymene, and Clymene are simply treated as the same person.

As a daughter of Minyas she belongs to the Minyan house of Orchomenus. Her mother is given as one of several women, probably Euryale, Clytodora, or Phanosyra (daughter of Paeon).

Her possible siblings, drawn from the various traditions of Minyas' offspring, include Clymene (in accounts that distinguish her from a same-named sister), Periclymene, Orchomenus, Presbon, Athamas, Diochthondas, Elara, Persephone, and the Minyades.

The sources disagree on whom Clymene married and which children she bore. In one tradition she is the wife of either Cephalus of Phocis or Phylacus, and the mother of Iphiclus and Alcimede. Through Alcimede this line connects her to the next generation of heroes.

Alternately, this same Clymene is named the wife of Iasus and the mother by him of Atalanta, the Arcadian huntress. The Atalanta tradition itself is split: one account makes Atalanta the Arcadian daughter of Iasus and Clymene, while another makes her the Boeotian daughter of King Schoeneus, a variation Wikipedia attributes to the way minor characters were often assigned different names in regional oral traditions.

Beyond her contested genealogy, Clymene appears in the catalogue of the dead: she is named as one of the souls encountered by Odysseus during his journey to the underworld.